Lumpectomy vs Mastectomy
Evidenced based reports on the data comparing survival and recurrence rates of Breast Conservation Therapy (Lumpectomy) vs Mastectomy in the treatment of breast cancer.
Breast Conservation Therapy (Lumpectomy)
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This article was where my journey into this topic began. As my blog post mentions, I joined a TNBC FB group and was surprised by how many TNBC women had or were planning to undergo mastectomy (see blog posts). This article from Memorial Sloan Kettering was first published in 2017 and my additional research in the years since support their conclusions. START YOUR DATA GATHERING HERE !
This abstract outlines a retrospective review of patients undergoing treatment of Stage 0-3 breast cancer from 2002 - 2011. DCIS, Stage I and Stage III patients showed no statistical advantage for mastectomy, while for Stage II patients with TNBC data was much better for BCT. (2020)
In patients suitable for either BCT or Mastectomy, this article confirms that patients treated with BCT had a lower rate of local, regional, and distant disease recurrences and at least comparable over all survival compared to those treated with mastectomy alone. (2021)
This article finds that survival benefit of BCT with radiotherapy was higher than or similar to that of total mastectomy in TNBC patients. (2021)
This is my concern - that somehow my sisters are convinced that there is some statistical advantage to choosing mastectomy over BCT. If such data exists, I have been unable to locate it.
Data from 8656 patients under the age of 40 diagnosed with invasive breast cancer between 2010 and 2014 was studied. Results indicated that BCT resulted in significantly better prognosis for patients with luminal and trip neg subtypes, while no signifcant difference was observed in patients with Her -2 subtype. (2020)
This Journal of the American Medical Association (JAMA) article studies 48,986 women and adds evidence to support the recommended use of Breast Conservation Therapy with Radiotherapy in both node-negative and node-positive breast cancer. (2021)
The National Center for Health Research discusses the efficacy of mastectomy for BRCA1 and BRCA2 breast cancer patients. Efficacy for other types of breast cancer patients is also discussed. (2021)
This study examined 419,000 women between the years 1992-2016 to ascertain contralateral (returning in the other breast) breast cancer recurrence rates. The 5 year contralateral recurrence rates for women under 50 years of age were 1.01% for original ER+ tumors and 1.89% for original ER- tumors. (2021)